Associations between insulin-like growth factor I, vascular endothelial growth factor and its soluble receptor 1 in umbilical serum and endothelial cells obtained from normotensive and preeclamptic pregnancies.
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| Abstract |
The aim of this study was to investigate the associations between insulin-like growth factor I (IGF-I) with vascular endothelial growth factor (VEGF) and its soluble receptor 1 (sFlt-1) in umbilical serum and to study the effects of IGF-I upon sFlt-1 synthesis in human umbilical vein endothelial cells (HUVEC) in normotensive (NT) and preeclamptic (PE) pregnancies. As compared with the NT group, umbilical serum IGF-I and VEGF levels were lower in the PE group, while sFlt-1 concentrations were higher. Levels of sFlt-1 correlated with IGF-I in the NT group and with VEGF in the PE group. Basal concentration of sFlt-1 in HUVEC culture media was higher in the PE group. IGF-I stimulated sFlt-1 synthesis only in the NT group. In summary, umbilical serum sFlt-1 is associated with IGF-I in normotensive pregnancy and with VEGF in preeclampsia. IGF-I stimulates sFlt-1 synthesis in endothelial cells in normotensive but not in PE pregnancies.
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| Authors | Andrea Olmos, Lorenza Díaz, Euclides Avila, David Barrera, Rebeca López-Marure, Benjamín Biruete, Fernando Larrea, Ali Halhali |
| Journal | Growth factors (Chur, Switzerland) (Growth Factors) Vol. 31 Issue 4 Pg. 123-9 (Aug 2013) ISSN: 1029-2292 [Electronic] England |
| PMID | 23750889 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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