Abstract | AIM: MATERIALS AND METHODS: Data from patients treated with either EQW or sita for 26 weeks in 2 randomized, double-blind, comparator-controlled clinical trials were pooled and analyzed. Glycemic endpoints and cardiovascular risk factors were evaluated in subgroups and the overall population. RESULTS: Analysis included 737 patients on background therapies of diet and exercise and/or metformin. While both agents reduced HbA1c and fasting blood glucose (FBG) levels from baseline, significantly greater reductions in HbA1c and FBG levels occurred with EQW compared with sita across all baseline HbA1c level strata, and significantly more patients in the EQW group achieved goal HbA1c levels compared with the sita group. Patients treated with EQW also experienced significantly greater reductions in body weight and cholesterol levels compared with patients treated with sita. The incidences of the most common adverse events of nausea and diarrhea were higher in the EQW group compared with the sita group, and incidences of these adverse events decreased over time. Both groups experienced a low incidence of minor hypoglycemic events. CONCLUSION: Significantly greater improvements in HbA1c and FBG levels were observed in EQW- compared with sita-treated patients across all baseline HbA1c level strata. Additionally, greater reductions in body weight and some cardiovascular risk factors were observed with EQW treatment compared with sita treatment. Both EQW and sita were generally well tolerated; sita-treated patients experienced fewer adverse events than EQW-treated patients. TRIAL REGISTRATION: www.ClinicalTrials.gov identifiers: NCT00637273, NCT00676338.
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Authors | Jaret Malloy, Alison Meloni, Jenny Han |
Journal | Postgraduate medicine
(Postgrad Med)
Vol. 125
Issue 3
Pg. 58-67
(May 2013)
ISSN: 1941-9260 [Electronic] England |
PMID | 23748507
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Blood Glucose
- Delayed-Action Preparations
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Peptides
- Pyrazines
- Triazoles
- Venoms
- hemoglobin A1c protein, human
- Exenatide
- Sitagliptin Phosphate
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Topics |
- Blood Glucose
(drug effects)
- Body Weight
(drug effects)
- Cardiovascular Diseases
(prevention & control)
- Delayed-Action Preparations
- Diabetes Mellitus, Type 2
(drug therapy)
- Double-Blind Method
- Exenatide
- Female
- Glycated Hemoglobin
(drug effects)
- Humans
- Hypoglycemic Agents
(administration & dosage, adverse effects, therapeutic use)
- Male
- Middle Aged
- Peptides
(administration & dosage, adverse effects, therapeutic use)
- Pyrazines
(adverse effects, therapeutic use)
- Retrospective Studies
- Risk Factors
- Sitagliptin Phosphate
- Triazoles
(adverse effects, therapeutic use)
- Venoms
(administration & dosage, adverse effects, therapeutic use)
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