[Long-term maintenance therapy in duodenal ulcer. Efficacy and safety].

Abstract

The efficacy and safety of continuous (maintenance) treatment with ranitidine has been studied retrospectively in 388 patients with duodenal ulcer. The cumulative rate of symptomatic relapse was 16% after 5 years. Very few of the patients developed ulcer complications during maintenance treatment, with a cumulative risk of haemorrhage of 1.8% during 5 years. The patients developed no drug-related disease. We conclude that long-term, continuous treatment with ranitidine is effective in maintaining remission of duodenal ulcers, protects the patients against the risk of complications, and is safe.

• Authors: J Penston, K G Wormsley
• Journal: Fortschritte der Medizin (Fortschr Med) Vol. 108 Issue 14 Pg. 282-6 (May 10 1990) ISSN: 0015-8178 [Print] Germany
• Vernacular Title: Langzeiterhaltungstherapie beim Ulcus duodeni. Wirksamkeit und Sicherheit.
• PMID: 2373457 (Publication Type: English Abstract, Journal Article)

Chemical References

• Ranitidine

Topics

• Adolescent
• Adult
• Aged
• Child
• Duodenal Ulcer (drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Peptic Ulcer Hemorrhage (prevention & control)
• Ranitidine (administration & dosage, therapeutic use)
• Recurrence
• Retrospective Studies
• Risk Factors
• Time Factors