Abstract | BACKGROUND AND OBJECTIVE: METHODS: A sleep study was performed in 29 newly diagnosed, clinically stable OHS patients. CPAP treatment was commenced if the apnoea-hypopnoea index was >15. Lung function, night-time oximetry, blood adipokine and C-reactive protein levels were assessed prospectively on enrollment and after 3 months. Treatment failure at 3 months was defined as daytime arterial partial pressure of carbon dioxide (PaCO(2)) >45 mm Hg and/or oxygen saturation (SpO(2)) <90% for >30% of the night-time oximetry study. RESULTS: All patients had severe OSA (median apnoea-hypopnoea index = 74.7 (62-100) with a nocturnal mean SpO(2) of 81.4 ± 7), and all patients were treated with CPAP. The percentage of time spent below 90% saturation improved from 8.4% (0.0-39.0%) to 0.3% (0.4-4.0%). Awake PaCO(2) decreased from 50 (47-53) mm Hg to 43 (40-45) mm Hg. Seven patients failed CPAP treatment after 3 months. PaCO(2) at 1 month and mean night-time SpO(2) during the first night of optimal CPAP were associated with treatment failure at 3 months (odds ratio 1.4 (1.03-1.98); P = 0.034 and 0.6 (0.34-0.93); P = 0.027). CONCLUSIONS: CPAP treatment improves night-time oxygenation and daytime hypoventilation in selected clinically stable OHS patients who also have OSA. Patients with worse night-time saturation while on CPAP and higher daytime PaCO(2) at 1 month were more likely to fail CPAP treatment.
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Authors | Neus Salord, Mercedes Mayos, Rosa Maria Miralda, Ariadna Farré, Montserrat Carreras, Rosa Sust, Cristina Masuet-Aumatell, Jose Rodríguez, Antonio Pérez |
Journal | Respirology (Carlton, Vic.)
(Respirology)
Vol. 18
Issue 7
Pg. 1135-42
(Oct 2013)
ISSN: 1440-1843 [Electronic] Australia |
PMID | 23714281
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology. |
Chemical References |
- Adipokines
- Oxyhemoglobins
- Carbon Dioxide
- C-Reactive Protein
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Topics |
- Adipokines
(metabolism)
- Aged
- C-Reactive Protein
(metabolism)
- Carbon Dioxide
(metabolism)
- Continuous Positive Airway Pressure
(methods)
- Female
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Obesity Hypoventilation Syndrome
(metabolism, therapy)
- Oximetry
- Oxyhemoglobins
(metabolism)
- Polysomnography
- Prospective Studies
- Retrospective Studies
- Severity of Illness Index
- Sleep Apnea, Obstructive
(metabolism, therapy)
- Treatment Outcome
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