Leptin and visfatin serum levels in non-diabetic ankylosing spondylitis patients undergoing TNF-α antagonist therapy.

Abstract

OBJECTIVES:

This paper aims to determine whether disease activity, systemic inflammation and metabolic syndrome are potential determinants of circulating leptin and visfatin levels in ankylosing spondylitis (AS) patients undergoing TNF-α antagonist therapy. We also assessed whether the infusion of infliximab may alter circulating leptin and visfatin concentrations in these patients.

METHODS:

We investigated leptin and visfatin serum concentrations in a series of 30 non-diabetic AS patients without history of cardiovascular (CV) events that were treated with the TNF-α antagonist infliximab, immediately prior to an infliximab infusion. Leptin and visfatin levels were also determined immediately after administration of an infliximab dose.

RESULTS:

Significant differences in leptin concentrations between men (8.85±5.31 ng/ml) and women (18.96±9.72 ng/ml) were observed (p=0.001). A significant correlation between visfatin concentrations and insulin resistance (HOMA at the time of the study) was found (r= 0.493; p=0.009). Circulating leptin and visfatin concentrations did not correlate with disease duration, erythrocyte sedimentation rate, C-reactive protein, BASDAI and VAS at the time of the study and adiponectin and resistin levels prior to infliximab infusion. Likewise, no differences in leptin and visfatin concentrations were observed when patients with a history of anterior uveitis or presence of syndesmophytes were compared with the remaining patients who did not exhibit these features. Leptin and visfatin levels did not change upon infliximab administration.

CONCLUSIONS:

The present study indicates that in non-diabetic patients with AS on treatment with infliximab leptin and visfatin serum levels do not correlate with disease activity or systemic inflammation. Nevertheless, visfatin concentration correlates with insulin resistance.

• Authors: José A Miranda-Filloy, Raquel López-Mejias, Fernanda Genre, Beatriz Carnero-López, Rodrigo Ochoa, Teresa Diaz de Terán, Carlos González-Juanatey, Ricardo Blanco, Javier Llorca, Miguel A González-Gay
• Journal: Clinical and experimental rheumatology (Clin Exp Rheumatol) 2013 Jul-Aug Vol. 31 Issue 4 Pg. 538-45 ISSN: 0392-856X [Print] Italy
• PMID: 23711190 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antirheumatic Agents
• Cytokines
• Leptin
• Tumor Necrosis Factor-alpha
• Infliximab
• Nicotinamide Phosphoribosyltransferase
• nicotinamide phosphoribosyltransferase, human

Topics

• Adipose Tissue (metabolism)
• Adult
• Aged
• Antibodies, Monoclonal (administration & dosage)
• Antirheumatic Agents (administration & dosage)
• Atherosclerosis (immunology, metabolism)
• Cytokines (blood)
• Diabetes Mellitus
• Female
• Humans
• Inflammation (immunology, metabolism)
• Infliximab
• Leptin (blood)
• Male
• Metabolic Syndrome (immunology, metabolism)
• Middle Aged
• Nicotinamide Phosphoribosyltransferase (blood)
• Spondylitis, Ankylosing (drug therapy, immunology, metabolism)
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)