Abstract | BACKGROUND: AIM: METHODS: The study design was a prospective, single blind randomised comparative study of adult patients mechanically ventilated for at least 4 days. Patients were randomised to Listerine(®) (Pfizer) oral rinse twice daily, sodium bicarbonate oral rinse 2/24 or sterile water 2/24 (control group). All groups received tooth brushing 3 times a day. Dental plaque colonisation (primary outcome) and incidence of ventilator associated pneumonia (secondary outcome) were studied. RESULTS: Three hundred and ninety-eight patients were randomised to either the Listerine group (127), sodium bicarbonate group (133) or the control group (138). Baseline characteristics were similar for all groups. There were no significant differences between the control and study groups in colonisation of dental plaque at Day 4 (p=0.243). Ventilator associated pneumonia was diagnosed in 18 patients. The incidence was, Listerine(®) group 4.7%, sodium bicarbonate group 4.5% and control 4.3% [OR, 0.99; 95% CI, 0.31 to 3.16; p=0.92]. CONCLUSIONS: Compared to the control group, Listerine(®) or sodium bicarbonate oral rinses were not more effective in the reduction of colonisation of dental plaque or the incidence of VAP. Given the low incidence of VAP, the common factor of a small, soft toothbrush as part of an oral hygiene regimen suggests possible benefit in mechanically ventilated patients.
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Authors | A M Berry |
Journal | Intensive & critical care nursing
(Intensive Crit Care Nurs)
Vol. 29
Issue 5
Pg. 275-81
(Oct 2013)
ISSN: 1532-4036 [Electronic] Netherlands |
PMID | 23692975
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Anti-Infective Agents, Local
- Drug Combinations
- Salicylates
- Terpenes
- Listerine
- Sodium Bicarbonate
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Topics |
- Anti-Infective Agents, Local
(therapeutic use)
- Dental Plaque
(microbiology)
- Drug Combinations
- Humans
- Incidence
- Intubation, Intratracheal
- Oral Hygiene
- Pneumonia, Ventilator-Associated
(prevention & control)
- Prospective Studies
- Salicylates
(therapeutic use)
- Single-Blind Method
- Sodium Bicarbonate
(therapeutic use)
- Terpenes
(therapeutic use)
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