A summary of meeting proceedings on addressing variability around the cut point in serial interferon-γ release assay testing.

Abstract

On June 13, 2012, a group of key stakeholders, leaders, and national experts on tuberculosis (TB), occupational health, and laboratory science met in Atlanta, Georgia, to focus national discussion on the higher than expected positive results occurring among low-risk, unexposed healthcare workers undergoing serial testing with interferon-γ release assays (IGRAs). The objectives of the meeting were to present the latest clinical and operational research findings on the topic, to discuss evaluation and treatment algorithms that are emerging in the absence of national guidance, and to develop a consensus on the action steps needed to assist programs and physicians in the interpretation of serial testing IGRA results. This report summarizes its proceedings.

• Authors: Charles L Daley, Randall R Reves, Melodie A Beard, Jeffrey Boyle, Richard B Clark, James L Beebe, Antonino Catanzaro, Lisa Chen, Edward Desmond, Susan E Dorman, T Warner Hudson, Alfred A Lardizabal, Hema Kapoor, David C Marder, Cyndee Miranda, Masahiro Narita, Lee Reichman, Dale Schwab, Barbara J Seaworth, Paul Terpeluk, Wendy Thanassi, L Masae Kawamura
• Journal: Infection control and hospital epidemiology (Infect Control Hosp Epidemiol) Vol. 34 Issue 6 Pg. 625-30 (Jun 2013) ISSN: 1559-6834 [Electronic] United States
• PMID: 23651895 (Publication Type: Congress, Research Support, Non-U.S. Gov't)

Topics

• Health Care Sector
• Humans
• Interferon-gamma Release Tests (standards)
• Occupational Health
• Practice Guidelines as Topic
• ROC Curve
• Tuberculosis (diagnosis, drug therapy, prevention & control)
• United States