[Efficacy of iodine-131 in treating hyperthyroid heart disease].

Abstract

OBJECTIVE:

To investigate the value of iodine-131 therapy for hyperthyroidism complicated hyperthyroid heart disease(HHD) induced by Graves' disease or Plummer disease.

METHODS:

Totally 40 HHD cases who were confirmed in our department from 2009 to 2010 were enrolled in this study. All patients received serum thyroid hormones and associated antibodies tests, 12-lead electrocardiogram, and/or thyroid imaging before and after iodine-131 therapy to access the treatment effectiveness.

RESULTS:

Among 31 patients with HHD due to Graves' disease and 9 due to Plummer disease, iodine-131 treatment resulted in euthyroidism in 15 and 5 patients and hypothyroid in 7 and 2 patients, while 9 and 2 remain hyperthyroid, respectively.Serum free triiodothyronine, free thyroxine, and thyroid-stimulating hormone were statistically significant(P<0.05) before and after iodine-131 therapy, while no significant difference for serum thyrotrophin receptor antibody, antithyroid peroxidase autoantibody, and anti-thyroglobulin antibody.Atrial fibrillation was the most common cardiac complication of hyperthyroidism(n=25, 62.5%) .The remission rate after iodine-131 treatment was 76.0%.

CONCLUSION:

Iodine-131 therapy can effectively and timely control hyperthyroid in HHD patients.

• Authors: Juan-Juan Song, Yan-Song Lin, Li Zhu, Fang Li
• Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 35 Issue 2 Pg. 166-70 (Apr 2013) ISSN: 1000-503X [Print] China
• PMID: 23643005 (Publication Type: English Abstract, Journal Article)

Chemical References

• Iodine Radioisotopes

Topics

• Adult
• Heart Diseases (drug therapy, etiology)
• Humans
• Hyperthyroidism (complications, drug therapy)
• Iodine Radioisotopes (therapeutic use)
• Middle Aged