Anti-inflammatory and anti-oxidative effects of corilagin in a rat model of acute cholestasis.

Abstract

BACKGROUND:

Nowadays, treatments for cholestasis remain largely nonspecific and often ineffective. Recent studies showed that inflammatory injuries and oxidative stress occur in the liver with cholestasis. In this study, we would use corilagin to treat the animal model of acute cholestasis in order to define the activity to interfere with inflammation-related and oxidative stress pathway in cholestatic pathogenesis.

METHODS:

Rats were administrated with alpha-naphthylisothiocyanate to establish model of cholestasis and divided into corilagin, ursodeoxycholic acid, dexamethasone, model and normal groups with treatment of related agent. At 24h, 48h and 72h time points after administration, living condition, serum markers of liver damage, pathological changes of hepatic tissue, nuclear factor (NF)-kappaB, myeloperoxidase (MPO), malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) were examined and observed.

RESULTS:

Compared to model group, corilagin had remarkable effect on living condition, pathological manifestation of liver tissue, total bilirubin, direct bilirubin, (P<0.01), but no effect on alanine aminotransferase (ALT) and aspartate aminotransferase (AST). With corilagin intervention, levels of MPO, MDA and translocation of NF-κB were notably decreased, and levels of SOD and NO were markedly increased (P<0.05 or P<0.01).

CONCLUSIONS:

It is shown that corilagin is a potential component to relieve cholestasis through inflammation-related and oxidation-related pathway.

• Authors: Feng Jin, Du Cheng, Jun-Yan Tao, Shu-Ling Zhang, Ran Pang, Yuan-Jin Guo, Pian Ye, Ji-Hua Dong, Lei Zhao
• Journal: BMC gastroenterology (BMC Gastroenterol) Vol. 13 Pg. 79 (May 03 2013) ISSN: 1471-230X [Electronic] England
• PMID: 23641818 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Cholagogues and Choleretics
• Glucosides
• Hydrolyzable Tannins
• NF-kappa B
• Nitric Oxide
• Malondialdehyde
• corilagin
• Ursodeoxycholic Acid
• Dexamethasone
• Peroxidase
• Superoxide Dismutase
• Aspartate Aminotransferases
• Alanine Transaminase
• Bilirubin

Topics

• Acute Disease
• Alanine Transaminase (blood)
• Analysis of Variance
• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Aspartate Aminotransferases (blood)
• Bilirubin (blood)
• Cholagogues and Choleretics (therapeutic use)
• Cholestasis (blood, drug therapy, pathology)
• Dexamethasone (pharmacology, therapeutic use)
• Disease Models, Animal
• Glucosides (pharmacology, therapeutic use)
• Hydrolyzable Tannins
• Liver (metabolism)
• Male
• Malondialdehyde (metabolism)
• NF-kappa B (biosynthesis)
• Nitric Oxide (metabolism)
• Oxidative Stress (drug effects)
• Peroxidase (metabolism)
• Rats
• Rats, Sprague-Dawley
• Superoxide Dismutase (metabolism)
• Ursodeoxycholic Acid (pharmacology, therapeutic use)