Double filtration plasmapheresis for a case of Crimean-Congo hemorrhagic fever.

Abstract

Crimean-Congo hemorrhagic fever (CCHF), is a fatal viral infection transmitted to humans through a tick bite or exposure to blood or tissues of viremic hosts. The clinical presentation is characterized by sudden onset high fever, headache, myalgia, abdominal pain and nausea-vomiting followed by gastrointestinal, urinary, respiratory tract and brain hemorrhage. Laboratory findings include leucopenia, thrombocytopenia, elevated liver enzymes, prolonged prothrombin time and activated partial thromboplastin time. We report a case of CCHF who was treated with a combination of DFPP and ribavirin therapy. As a result of this multimodal treatment, patient's clinical symptoms and laboratory findings improved gradually.

• Authors: Başak C Meço, Osman Memikoğlu, Osman Ilhan, Erol Ayyıldız, Ceren Gunt, Necmettin Unal, Mehmet Oral, Melek Tulunay
• Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 48 Issue 3 Pg. 331-4 (Jun 2013) ISSN: 1473-0502 [Print] England
• PMID: 23619328 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013. Published by Elsevier Ltd.

Chemical References

• Ribavirin
• Fibrinogen

Topics

• Adult
• Animals
• Fibrinogen (biosynthesis)
• Filtration
• Hemorrhagic Fever Virus, Crimean-Congo
• Hemorrhagic Fever, Crimean (therapy)
• Humans
• International Normalized Ratio
• Male
• Plasmapheresis (methods)
• Ribavirin (therapeutic use)
• Tick Bites
• Treatment Outcome
• Viral Load