Therapeutic plasma-exchange in hematologic disease: results from a single center in Eastern Anatolia.
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| Abstract |
Therapeutic plasma-exchange (TPE) is used as primary and adjunctive therapy in treatment of several hematologic diseases. We retrospectively evaluated the results of TPE in hematologic diseases during 2008-2012. A total of 301 TPE procedures were performed in 44 patients (19 male and 25 female, with mean age of 50.6±15years). Fifteen of 44 patients had thrombotic thrombocytopenic purpura (TTP), 14 patients had HELLP syndrome (Hemolysis Elevated Liver enzymes, Low Platelet count), 10 patients had multiple myeloma-hyperviscosity and the rest five patients had snake bite. Fresh frozen plasma (FFP) was used as replacement fluid. Complete response (CR) was achieved on 13 patients (87%) in primarily TTP. CR was achieved in all other three diseases. Total complications were detected in 8.1% of the TPE procedures. Adverse events (AEs), were seen in 5.4% of all procedures. None of the patients died from any complication. AE occurred in 4% (Grade-I), 1% (Grade-II), and 0.3% (Grade-III) of the procedures. The most common AE were nausea/vomiting, hypotension, pruritus and abdominal pain. TPE is effectively and safely carried out in our center in hematologic diseases.
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| Authors | Mehmet Ali Erkurt, Irfan Kuku, Emin Kaya, Unsal Ozgen, Ilhami Berber, Mustafa Koroglu, Mustafa Ozgül |
| Journal | Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 48 Issue 3 Pg. 335-9 (Jun 2013) ISSN: 1473-0502 [Print] England |
| PMID | 23619323 (Publication Type: Journal Article) |
| Copyright | Copyright © 2013 Elsevier Ltd. All rights reserved. |
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