Abstract |
Hepatocellular carcinoma (HCC) is the third leading cause of death by cancer worldwide. The prognosis of patients with metastatic HCC remains limited, with an expected median survival lower than 50% at 1 year. Here, we report the case of a 63-year-old man who suffered from a small HCC in the liver and a large unique metastasis in the right adrenal gland. A surgical resection of both lesions was performed. Seven months later, HCC recurred with an isolated right renal metastatic lymphadenopathy and a high alpha-fetoprotein level. HCC was brought under control by sorafenib; the alpha-fetoprotein level was greatly reduced but remained moderately elevated and stable over 2 years after the onset of chemotherapy. Additional external radiotherapy on the metastatic lymphadenopathy led to a normalization of the alpha-fetoprotein level and discontinuation of sorafenib treatment. One year after the end of radiotherapy, a second isolated metastasis occurred in the right lung. This tumor was surgically removed. Twenty-one months after this second surgical procedure, i.e., more than 5.5 years after the initial diagnosis of metastatic HCC, the patient was asymptomatic and tumor free.
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Authors | Charlène Brochard, Antoine Hamy, Sophie Michalak, Christophe Aubé, Jean Picquet, Nathalie Nebout, François-Xavier Caroli-Bosc, Frédéric Oberti, Paul Calès, Jérôme Boursier |
Journal | Clinics and research in hepatology and gastroenterology
(Clin Res Hepatol Gastroenterol)
Vol. 38
Issue 1
Pg. e19-22
(Feb 2014)
ISSN: 2210-741X [Electronic] France |
PMID | 23608740
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2013 Elsevier Masson SAS. All rights reserved. |
Topics |
- Adrenal Gland Neoplasms
(secondary, surgery, therapy)
- Carcinoma, Hepatocellular
(secondary, surgery, therapy)
- Humans
- Liver Neoplasms
(pathology)
- Male
- Middle Aged
- Palliative Care
- Remission Induction
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