Galectin-3 and left ventricular reverse remodelling after surgical mitral valve repair.

Abstract

AIMS:

Mitral valve repair in patients with functional mitral regurgitation (FMR) has been associated with beneficial left ventricular (LV) reverse remodelling. Recently, galectin-3 emerged as a marker of myocardial inflammation and fibrosis which may influence LV remodelling after surgery. The aim of the current study was to evaluate the association between pre-operative galectin-3 levels and LV reverse remodelling in heart failure patients with significant FMR who underwent mitral valve repair.

METHODS AND RESULTS:

In total, 42 heart failure patients (66 ± 10 years, 69% male) were evaluated. Plasma galectin-3 levels were assessed pre-operatively. Two-dimensional echocardiographic parameters were measured at baseline, and at 6 and 12 months after surgery. LV reverse remodelling was defined as a decrease in LV end-systolic volume ≥15% at 6 months follow-up. In total, 57% of the patients showed LV reverse remodelling. Patients with LV reverse remodelling showed significantly lower pre-operative galectin-3 levels (17.5 ± 5.6 vs. 23.7 ± 9.9 ng/mL, P = 0.009) compared with patients without LV reverse remodelling. In addition, patients with galectin-3 ≤18.2 ng/mL had a six-fold higher probability of showing LV reverse remodelling after surgery as compared with patients with levels >18.2 ng/mL (odds ratio 6.58, 95% confidence interval 1.32-33.33, P = 0.02).

CONCLUSION:

High pre-operative plasma galectin-3 is independently associated with the absence of LV reverse remodelling after mitral valve repair. Galectin-3 may be useful to identify heart failure patients who will need additional treatment to obtain beneficial LV reverse remodelling.

• Authors: Kirsten A Kortekaas, Georgette E Hoogslag, Rudolf A de Boer, Martin M Dokter, Michel I M Versteegh, Jerry Braun, Nina Ajmone Marsan, Hariette F Verwey, Victoria Delgado, Martin J Schalij, Robert J M Klautz
• Journal: European journal of heart failure (Eur J Heart Fail) Vol. 15 Issue 9 Pg. 1011-8 (Sep 2013) ISSN: 1879-0844 [Electronic] England
• PMID: 23576289 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Galectin 3
• Peptide Fragments
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain

Topics

• Aged
• Biomarkers (blood)
• Echocardiography
• Female
• Follow-Up Studies
• Galectin 3 (blood)
• Heart Failure (diagnostic imaging, physiopathology, surgery)
• Humans
• Male
• Middle Aged
• Mitral Valve Annuloplasty (methods)
• Mitral Valve Insufficiency (diagnostic imaging, physiopathology, surgery)
• Natriuretic Peptide, Brain (blood)
• Peptide Fragments (blood)
• Ventricular Remodeling (physiology)