Abstract |
Stress response during genital surgery was investigated in 18 female patients with CAH. Changes were studied in blood pH and base excess, in serum concentrations of sodium- and potassium ions, in concentrations of 17 OHP in serum and saliva. The following conclusions may be drawn: On the day of operation patients should receive 100 mg Prednisolut per square metre of body surface area i.v., divided in three doses. On postoperative days 1 and 2 the 4 to 6 fold, on postoperative days 3 and 4 the 2 to 3 fold amounts of supplementary doses of hydrocortisone should be administered. Fludrocortisone is substituted with 3-5 mg DCA i.m. only on the day of operation. It is convenient to use a half-isotonic solution of electrolytes with 5% glucose for the infusion therapy. A dose of 25-50 mg Prednisolut i.v. can be added to the substitution therapy before short diagnostic and therapeutic procedures with or without anaesthesia such as endoscopy or change of bandage. Radenarcon ( etomidate), used for induction of anesthesia, is contraindicated in patients with CAH.
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Authors | W Hoepffner, J Bennek, C Diestelhorst, L Wild |
Journal | Kinderarztliche Praxis
(Kinderarztl Prax)
Vol. 58
Issue 3
Pg. 151-7
(Mar 1990)
ISSN: 0023-1495 [Print] Germany |
Vernacular Title | Untersuchungen zur Anderung der Substitutionstherapie bei Patientinnen mit kongenitalem Adrenogenitalem Syndrom (AGS) im Rahmen operativer Eingriffe. |
PMID | 2355713
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Adrenal Cortex Hormones
- Hydroxyprogesterones
- 17-alpha-Hydroxyprogesterone
|
Topics |
- 17-alpha-Hydroxyprogesterone
- Adrenal Cortex Hormones
(administration & dosage)
- Adrenal Hyperplasia, Congenital
(blood, surgery)
- Child
- Child, Preschool
- Clitoris
(surgery)
- Combined Modality Therapy
- Female
- Humans
- Hydroxyprogesterones
(blood)
- Vagina
(surgery)
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