We report a case of urothelial
carcinoma (UC) in a 69-year-old man that occurred after
renal transplantation. He had started receiving
hemodialysis therapy in 2004 due to
diabetic nephropathy and underwent living related
renal transplantation from his brother in 2005. He was referred to our hospital in May 2009 with asymptomatic microscopic
hematuria. Cystoscopy findings revealed multiple
bladder tumors, and
transurethral resection of bladder tumor (TUR-BT) followed by
intravesical instillation of
pirarubicin was performed. Histopathological findings revealed UC (G1>G2, pTa). Cytology findings after the operation did not become negative; urine specimen from the native right ureter was positive, and abdominal computed tomography (CT) demonstrated a right pelvic
tumor. In January 2010, a laparoscopic right
nephroureterectomy was performed and pathological examination findings revealed UC in the right pelvis (G3>G2, INFβ, pT3). In March 2010, recurrence of the
bladder tumor was demonstrated as
carcinoma in situ (CIS) of the bladder and left native ureter. In June 2010, a
radical cystectomy with left
nephroureterectomy and
ileal conduit diversion were performed. One week after that operation, laboratory results revealed abnormal hepatic function and CT showed multiple liver
metastases. The patient died in August 2010, 2 months after surgery.