Abstract | BACKGROUND: METHODS AND RESULTS: Fifty AL- CMP patients were compared with 50 TTR- CMP patients (composed of 38 SSA and 12 ATTR patients). Clinical and laboratory evaluations including echocardiography were performed at the initial visit to our center and analyzed. Serum MMP-2, MMP-9, TIMP-1, and TIMP-2 levels were determined by ELISA. Compared with TTR- CMP patients, AL- CMP patients had higher levels of brain natriuretic peptide (BNP), troponin I (TnI), MMP-2, TIMP-1, and MMP-2/TIMP-2 ratio, despite less left ventricular (LV) hypertrophy and better preserved LV ejection fraction. Mortality was worse in AL- CMP patients than in TTR- CMP patients (log-rank P<0.01). MMP-2/TIMP-2 plus BNP and TnI showed the highest discriminative ability for distinguishing AL- CMP from TTR- CMP. Female sex (HR, 2.343; P=0.049) and BNP (HR, 1.041; P<0.01) were predictors for mortality for all patients with cardiac amyloidoses. Only BNP was a predictor of death in AL- CMP patients (HR, 1.090; P<0.01). There were no prognostic factors for all-cause death in TTR- CMP patients. CONCLUSIONS: Circulating concentrations of MMPs and TIMPs may be useful in differentiating patients with AL- CMP from those with TTR- CMP, resulting in earlier diagnostic vigilance, and may add prognostic information. In addition to an elevated BNP level, female sex increased the risk of death in patients with cardiac amyloidoses.
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Authors | Komei Tanaka, Eric E Essick, Gheorghe Doros, Kahraman Tanriverdi, Lawreen H Connors, David C Seldin, Flora Sam |
Journal | Journal of the American Heart Association
(J Am Heart Assoc)
Vol. 2
Issue 2
Pg. e005868
(Mar 12 2013)
ISSN: 2047-9980 [Electronic] England |
PMID | 23537813
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- TIMP1 protein, human
- TIMP2 protein, human
- Tissue Inhibitor of Metalloproteinase-1
- Tissue Inhibitor of Metalloproteinases
- Troponin I
- Natriuretic Peptide, Brain
- Tissue Inhibitor of Metalloproteinase-2
- Matrix Metalloproteinases
- MMP2 protein, human
- Matrix Metalloproteinase 2
- MMP9 protein, human
- Matrix Metalloproteinase 9
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Topics |
- Aged
- Amyloid Neuropathies, Familial
(blood, complications, diagnostic imaging)
- Amyloidosis
(blood, complications, diagnostic imaging)
- Cardiomyopathies
(blood, diagnostic imaging, etiology)
- Extracellular Matrix
(metabolism)
- Female
- Humans
- Hypertrophy, Left Ventricular
(diagnostic imaging)
- Male
- Matrix Metalloproteinase 2
(blood)
- Matrix Metalloproteinase 9
(blood)
- Matrix Metalloproteinases
(blood)
- Myocardium
(metabolism)
- Natriuretic Peptide, Brain
(blood)
- Stroke Volume
- Tissue Inhibitor of Metalloproteinase-1
(blood)
- Tissue Inhibitor of Metalloproteinase-2
(blood)
- Tissue Inhibitor of Metalloproteinases
(blood)
- Troponin I
(blood)
- Ultrasonography
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