Rice protein ameliorates the progression of diabetic nephropathy in Goto-Kakizaki rats with high-sucrose feeding.

Abstract	The effect of rice protein (RP) on diabetic nephropathy in non-obese, spontaneous type 2 diabetic Goto-Kakizaki (GK) rats was investigated.GK rats at 7 weeks of age were fed 20% RP or casein (C) in standard or high-sucrose diets for 10 weeks. Plasma total cholesterol,TAG, alkaline phosphatase (ALP), adiponectin, creatinine and urinary albumin excretion (UAE) were measured and renal histology was evaluated. Compared with C, RP lowered plasma TAG and improved plasma adiponectin levels in GK rats fed the standard diet (P<0·05), and also lowered total cholesterol and ALP in high-sucrose-fed GK rats (P<0·05). RP markedly suppressed the sharp increase in UAE when GK rats were fed high-sucrose diets (P<0·05), and prevented glomerular mesangial matrix expansion in the deep renal cortex near the corticomedullary junction (P<0·05). These results strongly indicate that dietary RP can ameliorate the progression of diabetic nephropathy at an early stage compared with C.
Authors	Masatoshi Kubota, Reiko Watanabe, Hideyuki Kabasawa, Noriaki Iino, Akihiko Saito, Takehisa Kumagai, Shinobu Fujimura, Motoni Kadowaki
Journal	The British journal of nutrition (Br J Nutr) Vol. 110 Issue 7 Pg. 1211-9 (Oct 2013) ISSN: 1475-2662 [Electronic] England
PMID	23537514 (Publication Type: Journal Article)
Chemical References	Adiponectin Caseins Dietary Proteins Dietary Sucrose Plant Proteins Triglycerides Cholesterol
Topics	Adiponectin (blood) Albuminuria (etiology) Animals Caseins (pharmacology) Cholesterol (blood) Diabetes Mellitus, Type 2 (complications, diet therapy, metabolism, pathology) Diabetic Nephropathies (complications, diet therapy, metabolism) Dietary Proteins (pharmacology, therapeutic use) Dietary Sucrose (adverse effects) Disease Progression Kidney (drug effects, pathology) Male Oryza (chemistry) Plant Proteins (pharmacology, therapeutic use) Rats Rats, Inbred Strains Rats, Wistar Triglycerides (blood)

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