Abstract |
A 72-year-old woman having abdominal pain and high fever was diagnosed with KRAS wild-type sigmoid colon cancer, invading the urinary bladder and uterus with a pelvic abscess. Considering the difficulty of curative resection, we first performed sigmoid colostomy and abscess drainage. Remarkable tumor regression was indicated by CT and colonoscopy after 1 course of FOLFIRI and 5 courses of FOLFIRI+panitumumab. Following an additional 2 courses of panitumumab, sigmoidectomy and partialcystectomy were performed. Six courses of FOLFIRI+panitumumab were administered postoperatively and no recurrence has been observed for 7 months. FOLFIRI+panitumumab may be an effective preoperative chemotherapy for patients with KRAS wild-type locally advanced colon cancer.
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Authors | Kohei Horioka, Keizo Kaku, Sei-ichirou Jimi, Yoshihiro Oohata, Takafumi Kamei |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 40
Issue 3
Pg. 397-9
(Mar 2013)
ISSN: 0385-0684 [Print] Japan |
PMID | 23507607
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- KRAS protein, human
- Proto-Oncogene Proteins
- Panitumumab
- Proto-Oncogene Proteins p21(ras)
- ras Proteins
- Leucovorin
- Fluorouracil
- Camptothecin
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Topics |
- Antibodies, Monoclonal
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Camptothecin
(administration & dosage, analogs & derivatives)
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Leucovorin
(administration & dosage)
- Middle Aged
- Neoadjuvant Therapy
- Neoplasm Invasiveness
- Panitumumab
- Proto-Oncogene Proteins
(genetics)
- Proto-Oncogene Proteins p21(ras)
- Sigmoid Neoplasms
(drug therapy, genetics, surgery)
- ras Proteins
(genetics)
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