Abstract |
Thirty adult patients with relapsed or refractory malignant lymphoma underwent a Phase I-II trial of salvage chemotherapy combining methyl-gag, high-dose Ara-C, M-Amsa, and ifosfamide ( MAMI protocol). All patients had been extensively pretreated. At the time of salvage therapy, 21 patients had visceral involvement and 23 patients were refractory. The overall response rate was 50% (11 patients in complete remission and 3 patients in partial remission). The main toxicity was myelosuppression; 4 treatment-related deaths occurred and 17 patients died of tumor progression with a median of 5 months. The MAMI protocol showed similar antitumoral efficacy to that of other salvage chemotherapy regimens used for poor prognosis malignant lymphoma but was more toxic. However, a response rate of 45% in refractory patients should be taken into account and this drug association deserves further investigation with regard to the selection of patients for bone marrow transplants.
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Authors | M Hayat, M Ostronoff, E Gilles, E Zambon, D Baume, A Moran, P Carde, J P Droz, J L Pico |
Journal | Cancer investigation
(Cancer Invest)
Vol. 8
Issue 1
Pg. 1-5
( 1990)
ISSN: 0735-7907 [Print] England |
PMID | 2350713
(Publication Type: Journal Article)
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Chemical References |
- Amsacrine
- Cytarabine
- Mitoguazone
- Ifosfamide
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Topics |
- Adolescent
- Adult
- Amsacrine
(administration & dosage, adverse effects)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Cytarabine
(administration & dosage, adverse effects)
- Dose-Response Relationship, Drug
- Female
- Humans
- Ifosfamide
(administration & dosage, adverse effects)
- Lymphoma
(drug therapy)
- Male
- Middle Aged
- Mitoguazone
(administration & dosage, adverse effects)
- Pilot Projects
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