Abstract |
The mechanism of intrauterine hepatitis B virus infection has not been established. In this study, venous blood, cord blood, and placental tissues from 171 chronic hepatitis B virus infected pregnant women were tested for hepatitis B surface antigen, hepatitis B core antigen, and hepatitis B virus DNA. We found that residence, mode of delivery, age, and number of gestational weeks of pregnant women were not correlated with intrauterine hepatitis B virus infection, while neonates of mothers who were hepatitis B s antigen positive and hepatitis B e antigen positive (P < 0.01) or who had high hepatitis B virus DNA levels (≥10(6) copies/ml) were more likely to get an intrauterine infection (P < 0.01). The hepatitis B virus infection rate in placental cell layers gradiently decreased from the mother's side to the fetus's side of the placenta, but the odds ratio value of correlation between placental hepatitis B virus infection and intrauterine infection gradiently increased. The way of intrauterine hepatitis B virus infection may be through a layer-layer transmission pathway, although the possibility of placental leakage cannot be excluded.
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Authors | Yong Chen, Lijuan Wang, Yunfang Xu, Xingxiang Liu, Shouzhong Li, Qiang Qian, Bin Hu, Aijun Zhou, Tianyan Chen, Yingren Zhao |
Journal | Microbes and infection
(Microbes Infect)
Vol. 15
Issue 5
Pg. 409-15
(May 2013)
ISSN: 1769-714X [Electronic] France |
PMID | 23500187
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. |
Chemical References |
- DNA, Viral
- Hepatitis B Core Antigens
- Hepatitis B Surface Antigens
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Topics |
- Adult
- DNA, Viral
(blood)
- Female
- Hepatitis B
(transmission, virology)
- Hepatitis B Core Antigens
(blood)
- Hepatitis B Surface Antigens
(blood)
- Hepatitis B virus
(isolation & purification)
- Humans
- Infant, Newborn
- Infectious Disease Transmission, Vertical
- Placenta
(virology)
- Pregnancy
- Pregnancy Complications, Infectious
(virology)
- Viremia
- Young Adult
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