Impact of age on myocardial uptake of ¹²³I-mIBG in older adult subjects without coronary heart disease.

Abstract

BACKGROUND:

The purpose of this study was to examine the relationship between myocardial uptake of (123)I-mIBG and age in older normal adult subjects.

METHODS:

94 subjects (age 29-82, mean 58.5) without coronary heart disease were studied. All subjects underwent early and delayed planar and 4-hour SPECT (123)I-mIBG imaging. (123)I-mIBG uptake was quantified as heart/mediastinum ratio on planar images (H/M p) and on SPECT images (H/M s) reconstructed by filtered backprojection, ordered subsets-expectation maximization (OSEM), and OSEM with compensation for collimator septal penetration (DSP). Relationships between age and (123)I-mIBG uptake were examined by correlation analysis, t-tests, and analysis of variance.

RESULTS:

There was no significant correlation between age and H/M p, reflecting comparable increases in activity in the two regions of interest with age. Results on SPECT analyses were comparable, with no significant correlation between age and H/M s. Using DSP, (123)I-mIBG H/M s was significantly higher in subjects ≥70 of age compared with younger subjects.

CONCLUSIONS:

Both cardiac and background uptake of (123)I-mIBG increase with age in older subjects without coronary heart disease, resulting in stability of H/M results (planar and SPECT). This study suggests that prognostic analyses of quantitative (123)I-mIBG uptake in patients with heart disease do not require adjustment for patient age.

• Authors: Arnold F Jacobson, Ji Chen, Liudmilla Verdes, Russell D Folks, Daya N Manatunga, Ernest V Garcia
• Journal: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (J Nucl Cardiol) Vol. 20 Issue 3 Pg. 406-14 (Jun 2013) ISSN: 1532-6551 [Electronic] United States
• PMID: 23483457 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Iodine Radioisotopes
• Radiopharmaceuticals
• 3-Iodobenzylguanidine
• Technetium

Topics

• 3-Iodobenzylguanidine
• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Coronary Disease (diagnostic imaging)
• Female
• Heart (diagnostic imaging)
• Humans
• Iodine Radioisotopes
• Male
• Middle Aged
• Myocardium (pathology)
• Radiographic Image Interpretation, Computer-Assisted
• Radiopharmaceuticals
• Reference Values
• Technetium
• Tomography, Emission-Computed, Single-Photon (methods)