Serum APE1 autoantibodies: a novel potential tumor marker and predictor of chemotherapeutic efficacy in non-small cell lung cancer.

Abstract	Apurinic/apyrimidinic endonuclease 1 (APE1), which has the dual functions of both DNA repair and redox activity, has been reported to be highly expressed in non-small cell lung cancer (NSCLC), and this appears to be a characteristic related to chemotherapy resistance. In this study, we identified serum APE1 autoantibodies (APE1-AAbs) in NSCLC patients and healthy controls by immunoblotting and investigated the expression of APE1-AAbs by indirect ELISA from the serum of 292 NSCLC patients and 300 healthy controls. In addition, serum APE1-AAbs level alterations of 91 patients were monitored before and after chemotherapy. Our results showed that serum APE1-AAbs can be detected in both NSCLC patients and healthy controls. Serum APE1-AAbs were significantly higher than those of healthy controls and closely related to APE1 antigen levels both in tumor tissues and the peripheral blood. Moreover, the change in levels of serum APE1-AAbs in NSCLC is closely associated with the response to chemotherapy. These results suggest that APE1-AAbs is a potential tumor marker and predictor of therapeutic efficacy in NSCLC.
Authors	Nan Dai, Xiao-Jing Cao, Meng-Xia Li, Yi Qing, Ling Liao, Xian-Feng Lu, Shi-Heng Zhang, Zheng Li, Yu-Xin Yang, Dong Wang
Journal	PloS one (PLoS One) Vol. 8 Issue 3 Pg. e58001 ( 2013) ISSN: 1932-6203 [Electronic] United States
PMID	23472128 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antigens Antineoplastic Agents Autoantibodies Biomarkers, Tumor APEX1 protein, human DNA-(Apurinic or Apyrimidinic Site) Lyase
Topics	Adult Aged Aged, 80 and over Antigens (immunology) Antineoplastic Agents (therapeutic use) Autoantibodies (blood) Biomarkers, Tumor (blood) Carcinoma, Non-Small-Cell Lung (diagnosis, drug therapy, metabolism) Case-Control Studies DNA-(Apurinic or Apyrimidinic Site) Lyase (immunology) Female Gene Expression Regulation, Neoplastic Humans Lung Neoplasms (diagnosis, drug therapy, metabolism) Male Middle Aged ROC Curve

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