Anti-Müllerian hormone and polycystic ovary syndrome: assessment of the clinical pregnancy rates in in vitro fertilization patients.

Abstract

OBJECTIVE:

The purpose of this study is to investigate the role of serum anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) for the prediction of clinical pregnancy rates (CPR) in women with polycystic ovary syndrome (PCOS) undergoing IVF treatment.

DESIGN:

Prospective cohort study.

SETTING:

University hospital.

PATIENTS:

One hundred and fifty consecutive women with PCOS.

INTERVENTIONS:

All women underwent controlled ovarian stimulation with long agonist protocol followed by IVF procedure. Outcomes of pregnant and non-pregnant groups were compared.

MAIN OUTCOME MEASURE:

CPR; AMH, FSH and AFC means and percentiles.

RESULTS:

Fifty-one (34%) clinical pregnancies were observed in 150 women. Mean AMH was 6.7 ± 2.8 and 7.1 ± 4.3 ng/mL in pregnant and non-pregnant women, respectively (p = 0.594). The CPR were 27.8%, 35.0% and 37.8% in <25%, 25%-75% and >75% AMH percentiles, respectively (p = 0.656). There were also no significant difference in mean FSH and AFC between pregnant and non-pregnant women (p = 0.484 and p = 0.165, respectively).

CONCLUSION:

AMH, FSH and AFC are not predictive for CPR in women with PCOS undergoing IVF treatment. Mean AMH values were not significantly different between pregnant and non-pregnant women. Although CRP increased in parallel with the raise in AMH percentiles, this remained insignificant.

• Authors: Sezai Sahmay, Onur Guralp, Begum Aydogan, Ismail Cepni, Engin Oral, Tulay Irez
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 29 Issue 5 Pg. 440-3 (May 2013) ISSN: 1473-0766 [Electronic] England
• PMID: 23461296 (Publication Type: Journal Article)

Chemical References

• Anti-Mullerian Hormone
• Follicle Stimulating Hormone

Topics

• Adult
• Anti-Mullerian Hormone (blood)
• Female
• Fertilization in Vitro
• Follicle Stimulating Hormone (blood)
• Humans
• Ovarian Follicle (cytology)
• Polycystic Ovary Syndrome (blood)
• Predictive Value of Tests
• Pregnancy
• Pregnancy Rate
• Prospective Studies
• Young Adult