MK-1 expression in gastric carcinoma with liver metastasis.

Abstract

OBJECTIVE:

The prognosis for gastric carcinoma patients with liver metastasis is very poor. This retrospective study investigated the prognostic significance of MK-1 expression in gastric carcinoma patients with liver metastasis.

METHODS:

Immunohistochemical staining using monoclonal antibody FU-MK-1 against MK-1 antigen was performed on paraffin-embedded tissues from 64 gastric carcinoma patients with liver metastasis. We attempted to determine the presence of any relationship between pathological prognostic factors and the expression of MK-1 in 64 gastric carcinoma patients with liver metastasis.

RESULTS:

MK-1 expression was found in 43 (67%) of 64 tumor samples. MK-1 expression was significantly higher in the intestinal type (73%) than in the diffuse type carcinoma (33%, P = 0.049). Multivariate analysis showed that MK-1 expression and lymph node metastasis were significant factors for overall survival. The difference between overall survival rates with positive or negative MK-1 expression was statistically significant as shown by Kaplan-Meier survival analysis (P < 0.0001; log-rank). In addition, the difference between cumulative disease-free survival rates with positive or negative MK-1 expression in gastric carcinoma patients with metachronous liver metastasis was statistically significant as well, as shown by Kaplan-Meier survival analysis (P = 0.0006; log-rank).

CONCLUSIONS:

The prognostic significance of MK-1 expression as a biological tumor marker was demonstrated in a series of gastric carcinoma patients with liver metastasis. MK-1 positivity may be a reliable marker for predicting and taking measures to control liver metastasis after curative gastrectomy for gastric carcinoma.

• Authors: Toru Miyake, Satoshi Nimura, Yoshihiro Hamada, Kazuki Nabeshima, Tetsuo Shinohara, Shinnosuke Tanaka, Yuichi Yamashita, Morishige Takeshita, Hiroshi Iwasaki
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 43 Issue 4 Pg. 377-82 (Apr 2013) ISSN: 1465-3621 [Electronic] England
• PMID: 23458716 (Publication Type: Journal Article)

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• Cell Adhesion Molecules
• EPCAM protein, human
• Epithelial Cell Adhesion Molecule

Topics

• Adult
• Aged
• Aged, 80 and over
• Antigens, Neoplasm (analysis)
• Biomarkers, Tumor (analysis)
• Cell Adhesion Molecules (analysis)
• Disease-Free Survival
• Epithelial Cell Adhesion Molecule
• Female
• Humans
• Immunohistochemistry
• Liver Neoplasms (secondary)
• Lymphatic Metastasis
• Male
• Middle Aged
• Prognosis
• Retrospective Studies
• Stomach Neoplasms (chemistry, mortality, pathology)