[Prevention of tuberculosis: current approaches to development of vaccines].

Abstract

This review is focused on recent advances in development of new vaccines for the prevention of tuberculosis. The main reasons for lack of BCG vaccine efficacy in different populations and geographic regions are presented. Design of new vaccines based on live modified strains of Mycobacterium bovis BCG, attenuated strains of Mycobacterium tuberculosis, recombinant proteins and viral vectors is considered in the specific examples. The usage of the heterologous "prime-boost" vaccination strategy against tuberculosis is discussed.

• Authors: M A Stukova, N V Zabolotnykh, T I Vinogradova, V Ia Gergert, A S Apt, A S Kaprel'iants, V V Erokhin, P K Iablonskiĭ, O I Kiselev
• Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk (Vestn Ross Akad Med Nauk) Issue 11 Pg. 45-52 ( 2012) ISSN: 0869-6047 [Print] Russia (Federation)
• PMID: 23457981 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Tuberculosis Vaccines
• Vaccines, Attenuated

Topics

• Animals
• Humans
• Tuberculosis (prevention & control)
• Tuberculosis Vaccines (pharmacology)
• Vaccination (trends)
• Vaccines, Attenuated