Abstract | BACKGROUND: METHODS: RESULTS:
miRNAs were higher in MI patients and correlated with LVEF (p < 0.001). Discrimination of MI was accurate for miR-208b (AUC = 0.82) and miR-499-5p (AUC = 0.79) but considerable lower than for Troponin T (AUC = 0.95). Increased miRNA levels were strongly associated with increased risk of mortality or heart failure within 30 days for miR-208b (OR 1.79, 95% CI = 1.38-2.23, p = 1 × 10(-5)) and miR-499-5p (OR 1.70, 95% CI = 1.31-2.20, p = 5 × 10(-5)) but the association was lost when adjusting for Troponin T. During surgery miR-208b and miR-499-5p was released in the coronary sinus after cardioplegia-reperfusion to markedly higher levels than in a peripheral vein. CONCLUSIONS: Our findings confirm increased levels of cardio-enriched miRNAs in the blood of MI patients and establish association of increased miRNA levels with reduced systolic function after MI and risk of death or heart failure.
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Authors | Olof Gidlöf, J Gustav Smith, Kazuma Miyazu, Patrik Gilje, Anna Spencer, Sten Blomquist, David Erlinge |
Journal | BMC cardiovascular disorders
(BMC Cardiovasc Disord)
Vol. 13
Pg. 12
(Feb 28 2013)
ISSN: 1471-2261 [Electronic] England |
PMID | 23448306
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Genetic Markers
- MIRN208 microRNA, human
- MIRN499 microRNA, human
- MicroRNAs
- Troponin T
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Topics |
- Aged
- Aged, 80 and over
- Analysis of Variance
- Area Under Curve
- Coronary Artery Bypass
- Discriminant Analysis
- Female
- Genetic Markers
- Genetic Testing
(methods)
- Heart Arrest, Induced
- Heart Failure
(etiology, genetics, physiopathology)
- Humans
- Male
- MicroRNAs
(blood)
- Middle Aged
- Myocardial Infarction
(blood, complications, genetics, mortality, physiopathology, surgery)
- Odds Ratio
- Predictive Value of Tests
- Prognosis
- Real-Time Polymerase Chain Reaction
- Risk Factors
- Stroke Volume
- Systole
- Time Factors
- Troponin T
(blood)
- Up-Regulation
- Ventricular Dysfunction, Left
(blood, genetics, physiopathology)
- Ventricular Function, Left
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