[Antineoplastic and immunostimulating effects of several N-vinylpyrrolidone co(ter)polymers in C3HA strain mice with hepatoma 22a].

Abstract

The antitumor and immunoadjuvant action of water-soluble N-vinylpyrrolidone co(ter)polymers of different chemical structure is studied. It is established that terpolymer N-vinyl-pyrrolidone (VP)--crotonic acid (CA)--n-crotonoylaminophenol inhibiting the growth of hepatoma 22a by 50-60% possesses an antitumoral action, while copolymer VP-CA has an immunoadjuvant action. These properties of co(ter)polymers are due to their chemical structure and molecular weight, but they do not always correlate between themselves.

• Authors: T A Korosteleva, K S Movsesian, M V Solovskiĭ, E F Panarin, O V Nazarova, I S Kochetkova
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 12 Issue 3 Pg. 53-5 ( 1990) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Protivoopukholevoe i immunostimuliruiushchee deĭstvie nekotorykh co(ter)polimerov N-vinilpirrolidona na mysheĭ linii C3HA s gepatomoĭ 22a.
• PMID: 2344826 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antineoplastic Agents
• Crotonates
• Polymers
• Pyrrolidinones
• N-vinyl-2-pyrrolidinone

Topics

• Adjuvants, Immunologic (therapeutic use)
• Animals
• Antineoplastic Agents (therapeutic use)
• Crotonates (therapeutic use)
• Liver Neoplasms, Experimental (drug therapy)
• Mice
• Mice, Inbred C3H
• Molecular Weight
• Polymers
• Pyrrolidinones (therapeutic use)