[The improvement of immunobiological preparations against leptospirosis. An experimental study of a new concentrated purified vaccine against icterohemorrhagic leptospirosis for human immunization].

Abstract

The findings of the study of immunological structure of the population in regions endemic for leptospirosis indicate that the immune status of humans makes it impossible to obtain titrated blood sera for the preparation of antileptospirosis immunoglobulin. The data obtained in the study of the immunobiological properties of a new concentrated vaccine against icterohemorrhagic leptospirosis show the possibility of using this vaccine for the immunization of donors with the aim of obtaining blood sera to be used as raw material for the production of immunobiological preparations.

• Authors: E A Iagovkin, N I Kostina, B F Vachaev, T P Romantsova, V F Kondratenko, I E Bunin, Z A Gol'denshteĭn, Iu V Anan'ina
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 2 Pg. 47-51 (Feb 1990) ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Sovershenstvovanie immunobiologicheskikh protivoleptospiroznykh preparatov. Eksperimental'noe izuchenie novoĭ kontsentrirovannoĭ ochishchennoĭ vaktsiny protiv ikterogemorragicheskogo leptospiroza dlia immunizatsii liudeĭ.
• PMID: 2343683 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Bacterial
• Bacterial Vaccines

Topics

• Animals
• Antibodies, Bacterial (analysis)
• Bacterial Vaccines (immunology, isolation & purification, toxicity)
• Cricetinae
• Disease Reservoirs
• Drug Evaluation, Preclinical
• Guinea Pigs
• Humans
• Immunization
• Leptospira interrogans (immunology)
• Mice
• Rabbits
• USSR
• Weil Disease (immunology, mortality, prevention & control)