Abstract | PURPOSE: METHODS AND MATERIALS: Patients with 1 to 3 liver metastases, with maximum individual tumor diameters less than 6 cm and a Karnofsky Performance Status of at least 70, were enrolled and treated by SBRT on a phase 2 clinical trial. Dose prescription was 75 Gy on 3 consecutive days. SBRT was delivered using the volumetric modulated arc therapy by RapidArc (Varian, Palo Alto, CA) technique. The primary end-point was in-field local control. Secondary end-points were toxicity and survival. RESULTS: Between February 2010 and September 2011, a total of 61 patients with 76 lesions were treated. Among the patients, 21 (34.3%) had stable extrahepatic disease at study entry. The most frequent primary sites were colorectal (45.9%) and breast (18%). Of the patients, 78.7% had 1 lesion, 18.0% had 2 lesions, and 3.3% had 3 lesions. After a median of 12 months (range, 2-26 months), the in-field local response rate was 94%. The median overall survival rate was 19 months, and actuarial survival at 12 months was 83.5%. None of the patients experienced grade 3 or higher acute toxicity. No radiation-induced liver disease was detected. One patient experienced G3 late toxicity at 6 months, resulting from chest wall pain. CONCLUSIONS: SBRT for unresectable liver metastases can be considered an effective, safe, and noninvasive therapeutic option, with excellent rates of local control and a low treatment-related toxicity.
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Authors | Marta Scorsetti, Stefano Arcangeli, Angelo Tozzi, Tiziana Comito, Filippo Alongi, Pierina Navarria, Pietro Mancosu, Giacomo Reggiori, Antonella Fogliata, Guido Torzilli, Stefano Tomatis, Luca Cozzi |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 86
Issue 2
Pg. 336-42
(Jun 01 2013)
ISSN: 1879-355X [Electronic] United States |
PMID | 23433800
(Publication Type: Clinical Trial, Phase II, Journal Article)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Topics |
- Adult
- Aged
- Aged, 80 and over
- Feasibility Studies
- Female
- Humans
- Karnofsky Performance Status
- Liver Neoplasms
(mortality, pathology, secondary, surgery)
- Male
- Middle Aged
- Prospective Studies
- Radiosurgery
(adverse effects, methods, mortality)
- Radiotherapy Planning, Computer-Assisted
(methods)
- Radiotherapy, Intensity-Modulated
(adverse effects, methods, mortality)
- Tumor Burden
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