NSCLC subtype prediction using cytologic fluid specimens from needle aspiration biopsies.

Abstract	This study evaluated the diagnostic usefulness of tumor marker concentrations in cytologic fluids (CF) for subtyping non-small cell lung cancer (NSCLC) and assessed the relationship between fluorine-18-fluorodeoxyglucose ((18)F-FDG) uptake with serum and CF tumor marker levels. This prospective study included 88 patients diagnosed with adenocarcinoma or squamous cell carcinoma (SCC). Cytokeratin-19 fragment (CYFRA 21-1), carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCCA) concentrations in the CF samples were correlated with serum tumor marker concentrations, (18)F-FDG uptake, and NSCLC subtype. Fifty-eight patients were diagnosed with adenocarcinoma. Multivariate analysis revealed higher CF and serum SCCA levels; smoking status predicted SCC from adenocarcinoma. CF SCCA showed the highest accuracy (83%) in distinguishing between SCC and adenocarcinoma. CF samples obtained during routine needle aspiration biopsy procedure contain tumor marker levels sufficient to distinguish between SCC and adenocarcinoma; CF SCCA had the highest diagnostic accuracy.
Authors	Arthur Cho, Jin Hur, Yoo Jin Hong, Hye-Jeong Lee, Young Jin Kim, Hee Yeong Kim, Ji Won Lee, Hyo Sup Shim, Byoung Wook Choi
Journal	American journal of clinical pathology (Am J Clin Pathol) Vol. 139 Issue 3 Pg. 309-16 (Mar 2013) ISSN: 1943-7722 [Electronic] England
PMID	23429366 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antigens, Neoplasm Biomarkers, Tumor Carcinoembryonic Antigen Keratin-19 Radiopharmaceuticals antigen CYFRA21.1 Fluorodeoxyglucose F18
Topics	Aged Antigens, Neoplasm (analysis) Area Under Curve Biomarkers, Tumor (analysis) Biopsy, Needle Body Fluids (chemistry) Carcinoembryonic Antigen (analysis) Carcinoma, Non-Small-Cell Lung (diagnosis, diagnostic imaging, surgery) Cytodiagnosis Female Fluorodeoxyglucose F18 Humans Keratin-19 (analysis) Lung Neoplasms (diagnosis, diagnostic imaging, surgery) Male Positron-Emission Tomography ROC Curve Radiopharmaceuticals Sensitivity and Specificity

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