Endotoxin adsorption by polymyxin B column or intraaortic balloon pumping use for severe septic cardiomyopathy.

Abstract

Septic patients often have low cardiac output. Some of them present severe cardiac dysfunction such as septic cardiomyopathy. However, no well-known and effective treatment for septic cardiomyopathy exists. The effect of endotoxin adsorption by polymyxin B–immobilized fiber column–direct hemoperfusion (PMX-DHP) and intraaortic balloon pumping (IABP) for septic shock remains uncertain. We experienced 2 very contrastive case reports of severe septic cardiomyopathy. We experienced 2 cases of severe septic cardiomyopathy with refractory shock. Case 1 with colon perforation presented refractory shock 6 hours after PMX-DHP, and IABP immediately improved her hemodynamics. In contrast, IABP had no effect at all in case 2 with viral enteritis, but PMXDHP improved her blood pressure and stroke volume markedly. The probability of impaired coronary microcirculation and relative bradycardia is the least required conditions for IABP use in severe septic cardiomyopathy. Meanwhile, PMX-DHP could be a good option for septic cardiomyopathy because of its fewer complications.

• Authors: Kensuke Nakamura, Kent Doi, Ryota Inokuchi, Tatsuma Fukuda, Takahiro Hiruma, Takeshi Ishii, Susumu Nakajima, Eisei Noiri, Naoki Yahagi
• Journal: The American journal of emergency medicine (Am J Emerg Med) Vol. 31 Issue 5 Pg. 893.e1-3 (May 2013) ISSN: 1532-8171 [Electronic] United States
• PMID: 23399331 (Publication Type: Case Reports, Journal Article)

Chemical References

• Endotoxins
• Polymyxin B

Topics

• Aged
• Cardiomyopathies (etiology, therapy)
• Combined Modality Therapy
• Endotoxins
• Female
• Hemoperfusion (methods)
• Humans
• Intra-Aortic Balloon Pumping
• Polymyxin B
• Shock, Septic (complications, therapy)
• Young Adult