Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma.

Abstract

We report an adult T-cell leukemia/lymphoma patient suffering from Stevens-Johnson Syndrome (SJS) during mogamulizumab (humanized anti-CCR4 monoclonal antibody) treatment. There was a durable significant reduction of the CD4(+) CD25(high) FOXP3(+) regulatory T (Treg) cell subset in the patient's PBMC, and the affected inflamed skin almost completely lacked FOXP3-positive cells. This implies an association between reduction of the Treg subset by mogamulizimab and occurrence of SJS. The present case should contribute not only to our understanding of human pathology resulting from therapeutic depletion of Treg cells, but also alert us to the possibility of immune-related severe adverse events such as SJS when using mogamulizumab. We are currently conducting a clinical trial of mogamulizumab for CCR4-negative solid cancers (UMIN000010050), specifically aiming to deplete Treg cells.

• Authors: Takashi Ishida, Asahi Ito, Fumihiko Sato, Shigeru Kusumoto, Shinsuke Iida, Hiroshi Inagaki, Akimichi Morita, Shiro Akinaga, Ryuzo Ueda
• Journal: Cancer science (Cancer Sci) Vol. 104 Issue 5 Pg. 647-50 (May 2013) ISSN: 1349-7006 [Electronic] England
• PMID: 23360455 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 Japanese Cancer Association.

Chemical References

• Antibodies, Monoclonal, Humanized
• mogamulizumab

Topics

• Aged
• Antibodies, Monoclonal, Humanized (adverse effects, therapeutic use)
• Female
• Humans
• Leukemia-Lymphoma, Adult T-Cell (drug therapy, immunology)
• Stevens-Johnson Syndrome (chemically induced, immunology)