Abstract | CONTEXT:
Cushing's disease (CD) is associated with serious morbidity and, when suboptimally treated, an increased mortality. Although surgery is the first-line treatment modality for CD, hypercortisolism persists or recurs in an important subset of patients. Considering the deleterious effects of uncontrolled CD, there is a clear need for effective medical therapy. OBJECTIVE: In this review, we discuss molecular targets for medical therapy, efficacy, and side effects of the currently used drugs to treat hypercortisolism and focus on recent developments resulting from translational and clinical studies. EVIDENCE ACQUISITION: Selection of publications related to the study objective was performed via a PubMed search using relevant keywords and search terms. MAIN FINDINGS: CONCLUSION: Medical therapy for CD can be targeted at different levels and should be tailored in each individual patient. Future studies should examine the optimal dose and combination of medical treatment modalities for CD.
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Authors | Richard A Feelders, Leo J Hofland |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 98
Issue 2
Pg. 425-38
(Feb 2013)
ISSN: 1945-7197 [Electronic] United States |
PMID | 23345100
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents, Hormonal
- Dopamine Agonists
- Receptors, Glucocorticoid
- Somatostatin
- Mitotane
- pasireotide
- Octreotide
|
Topics |
- Antineoplastic Agents, Hormonal
(therapeutic use)
- Dopamine Agonists
(therapeutic use)
- Humans
- Mitotane
(therapeutic use)
- Octreotide
(therapeutic use)
- Pituitary ACTH Hypersecretion
(drug therapy)
- Receptors, Glucocorticoid
(antagonists & inhibitors)
- Somatostatin
(analogs & derivatives, therapeutic use)
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