Antibody-dependent cell-mediated virus inhibition antibody activity does not correlate with risk of HIV-1 superinfection.

Abstract

Previous studies of HIV-infected women with high-risk behavior have indicated that neither neutralizing antibody nor cellular immunity elicited by an initial HIV-1 infection is associated with protection against superinfection with a different HIV-1 strain. Here, we measured antibody-dependent cell-mediated virus inhibition (ADCVI) antibody activity in the plasma of 12 superinfected cases and 36 singly infected matched controls against 2 heterologous viruses. We found no association between plasma ADCVI activity and superinfection status. ADCVI antibody activity against heterologous virus elicited by the original infection may not contribute to preventing a superinfecting HIV-1.

• Authors: Donald N Forthal, Gary Landucci, Bhavna Chohan, Barbra A Richardson, R Scott McClelland, Walter Jaoko, Catherine Blish, Julie Overbaugh
• Journal: Journal of acquired immune deficiency syndromes (1999) (J Acquir Immune Defic Syndr) Vol. 63 Issue 1 Pg. 31-3 (May 01 2013) ISSN: 1944-7884 [Electronic] United States
• PMID: 23344546 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Antibodies, Neutralizing
• HIV Antibodies

Topics

• Antibodies, Neutralizing (blood, immunology)
• Antibody-Dependent Cell Cytotoxicity (immunology)
• Case-Control Studies
• Female
• HIV Antibodies (blood, immunology)
• HIV Infections (immunology, virology)
• HIV-1 (classification, genetics, immunology, pathogenicity)
• Humans
• Kenya
• Superinfection (immunology, prevention & control, virology)