Abstract | BACKGROUND: METHODS: In this placebo-controlled study, we investigated the effects of amitriptyline (5 mg/kg), gabapentin (50 mg/kg), and minocycline (25 mg/kg) twice a day on NP behavior in a sciatic chronic constriction injury (CCI) rat model. Drug treatment started 7 days after CCI and lasted 14 days. At postoperative day 21, spinal BDNF expression in laminae I and II was quantified using immunocytochemistry. RESULTS: CONCLUSIONS:
Minocycline and amitriptyline both reduce NP behavior in a sciatic CCI rat model, but only minocycline reduces spinal BDNF, indicating different modes of action of these 2 drugs. The observed actions of minocycline closely fit the clinical needs for the treatment of NP.
|
Authors | Pascal Vanelderen, Tom Rouwette, Tamás Kozicz, René Heylen, Jan Van Zundert, Eric W Roubos, Kris Vissers |
Journal | Regional anesthesia and pain medicine
(Reg Anesth Pain Med)
2013 Mar-Apr
Vol. 38
Issue 2
Pg. 124-30
ISSN: 1532-8651 [Electronic] England |
PMID | 23337936
(Publication Type: Journal Article)
|
Chemical References |
- Amines
- Analgesics
- Brain-Derived Neurotrophic Factor
- Cyclohexanecarboxylic Acids
- Amitriptyline
- gamma-Aminobutyric Acid
- Gabapentin
- Minocycline
|
Topics |
- Amines
(administration & dosage)
- Amitriptyline
(administration & dosage)
- Analgesics
(administration & dosage)
- Animals
- Behavior, Animal
(drug effects)
- Brain-Derived Neurotrophic Factor
(metabolism)
- Constriction
- Cyclohexanecarboxylic Acids
(administration & dosage)
- Disease Models, Animal
- Down-Regulation
- Drug Administration Schedule
- Gabapentin
- Hyperalgesia
(diagnosis, drug therapy, metabolism, physiopathology, psychology)
- Immunohistochemistry
- Male
- Minocycline
(administration & dosage)
- Neuralgia
(diagnosis, drug therapy, metabolism, physiopathology, psychology)
- Pain Measurement
- Pain Perception
(drug effects)
- Pain Threshold
(drug effects)
- Posterior Horn Cells
(drug effects, metabolism)
- Rats
- Rats, Sprague-Dawley
- Sciatic Nerve
(surgery)
- Spinal Cord
(drug effects, metabolism, physiopathology)
- Time Factors
- gamma-Aminobutyric Acid
(administration & dosage)
|