Abstract | OBJECTIVE: DESIGN: Prospective, randomized animal study. SETTING: University laboratory. SUBJECTS: Newborn (1-5 days old) pigs. INTERVENTIONS: Cerebral perfusion pressure and pial artery diameter were determined before and after lateral fluid percussion brain injury was produced in piglets equipped with a closed cranial window. Dopamine (15 µg/kg/min IV) was administered 30 mins post fluid percussion injury. Cerebrospinal fluid ERK MAPK was determined by enzyme-linked immunosorbent assay. MEASUREMENTS AND MAIN RESULTS:
Dopamine increased cerebral perfusion pressure equivalently in both sexes and prevented sex-dependent reductions in pial artery diameter after fluid percussion injury. Loss of pial artery dilation during hypotension was greater in male than in female piglets after fluid percussion injury, but dopamine prevented such impairment equivalently in both sexes post injury. endothelin-1 and ERK MAPK release was greater in male compared to female piglets after fluid percussion injury, but dopamine also blocked their up-regulation equivalently in male and female piglets after fluid percussion injury. CONCLUSIONS: These data indicate that dopamine is protective of autoregulation after fluid percussion injury in both sexes. These observations advocate for the consideration of development of sex based therapies for treatment of hemodynamic sequalae of pediatric traumatic brain injury.
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Authors | William M Armstead, John Riley, Monica S Vavilala |
Journal | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
(Pediatr Crit Care Med)
Vol. 14
Issue 2
Pg. e103-11
(Feb 2013)
ISSN: 1529-7535 [Print] United States |
PMID | 23314184
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Endothelin-1
- Sympathomimetics
- Extracellular Signal-Regulated MAP Kinases
- Dopamine
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Topics |
- Analysis of Variance
- Animals
- Blood Pressure
(drug effects)
- Brain Injuries
(drug therapy, physiopathology)
- Cerebrovascular Circulation
(drug effects, physiology)
- Dopamine
(pharmacology, therapeutic use)
- Endothelin-1
(metabolism)
- Extracellular Signal-Regulated MAP Kinases
(metabolism)
- Female
- Hypotension
(prevention & control)
- MAP Kinase Signaling System
(drug effects)
- Male
- Sex Factors
- Swine
- Sympathomimetics
(pharmacology, therapeutic use)
- Up-Regulation
(drug effects)
- Vasodilation
(drug effects)
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