Abstract | OBJECTIVE: METHODS: Ten CADASIL patients and 10 healthy subjects were included in the study. All subjects underwent a transcranial magnetic stimulation study examining different intracortical circuits. Sensorimotor plasticity was also assessed using a paired associative stimulation and extensive neuropsychological tests. RESULTS:
CADASIL patients showed a lack of intracortical facilitation, short latency afferent inhibition and sensorimotor plasticity when compared with control subjects. CADASIL patients also showed an altered neuropsychological profile. Correlation between sensorimotor plasticity and neuropsychological alterations was observed in CADASIL patients. CONCLUSIONS:
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Authors | Francisco J Palomar, Aida Suárez, Emilio Franco, Fátima Carrillo, Eulogio Gil-Néciga, Pablo Mir |
Journal | Journal of neurology, neurosurgery, and psychiatry
(J Neurol Neurosurg Psychiatry)
Vol. 84
Issue 3
Pg. 329-36
(Mar 2013)
ISSN: 1468-330X [Electronic] England |
PMID | 23308019
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- CADASIL
(physiopathology, psychology)
- Case-Control Studies
- Cerebral Cortex
(physiopathology)
- Electromyography
(methods, psychology)
- Evoked Potentials, Motor
(physiology)
- Female
- Humans
- Male
- Middle Aged
- Neural Pathways
(physiopathology)
- Neuronal Plasticity
(physiology)
- Neuropsychological Tests
(statistics & numerical data)
- Transcranial Magnetic Stimulation
(methods, psychology)
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