Neolignans from leaves of Miliusa mollis.

Abstract

From the leaves of Miliusa mollis Pierre (Annonaceae), five new dihydrobenzofuran neolignans, namely miliumollin, 7-methoxymiliumollin, 3'-methoxymiliumollin, 4'-O-methylmiliumollin and miliumollinone, and a new 8-O-4' neolignan named miliusamollin were isolated, and their structures were elucidated through analysis of spectroscopic data. Miliumollin, 3'-methoxymiliumollin, miliumollinone and decurrenal exhibited weak cytotoxicity against KB, MCF7 and NCI-H187 cells. Miliumollinone possessed weak inhibitory effects against herpes simplex virus types 1 and 2. None of the isolates displayed inhibitory activity against avian influenza H5N1 neuraminidase.

• Authors: Kanokporn Sawasdee, Tanawat Chaowasku, Vimolmas Lipipun, Thi-Hanh Dufat, Sylvie Michel, Kittisak Likhitwitayawuid
• Journal: Fitoterapia (Fitoterapia) Vol. 85 Pg. 49-56 (Mar 2013) ISSN: 1873-6971 [Electronic] Netherlands
• PMID: 23305777 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents, Phytogenic
• Antiviral Agents
• Lignans

Topics

• Annonaceae (chemistry)
• Antineoplastic Agents, Phytogenic (isolation & purification)
• Antiviral Agents (isolation & purification)
• Drug Screening Assays, Antitumor
• Humans
• Lignans (isolation & purification)
• MCF-7 Cells
• Microbial Sensitivity Tests
• Molecular Structure
• Plant Leaves (chemistry)