Abstract | BACKGROUND: Non-steroidal anti-inflammatory drugs ( NSAIDs) and proton pump inhibitors (PPIs) are regarded as two types of drugs that respectively increase and decrease the risk of peptic ulcer bleeding. However, their relation to occurrence, recurrence and death of bleeding in the population level is not clear. STUDY OBJECTIVE: DESIGN: Ecological study. RESULTS: The time trend of peptic ulcer bleeding did not correlate with PPI sales but did correlate with NSAIDs in mem (R(male)=0.6571, P(male)=0.05). Sales of PPIs (inverse) and NSAIDs correlated with re- bleeding in women (R(male)=-0.8754, P(male)=0.002 and R(female)=0.7161, P(female)=0.03, respectively), but not in men. An inverse correlation between PPI sales and 30-day death after bleeding was found (R(male)=-0.9392, P(male)=0.0002 and R(female)=-0.8561, P(female)=0.003), and NSAID sales were found to correlate with increased death after bleeding ((R(male)=0.7278, P(male)=0.03, R(female)=0.7858, P(female)=0.01). CONCLUSIONS:
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Authors | Yunxia Lu, Emma Sverdén, Rickard Ljung, Claes Söderlund, Jesper Lagergren |
Journal | BMJ open
(BMJ Open)
Vol. 3
Issue 1
(Jan 03 2013)
ISSN: 2044-6055 [Electronic] England |
PMID | 23293249
(Publication Type: Journal Article)
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