Abstract | BACKGROUND: Skin ageing is influenced by environmental factors such as ultraviolet (UV) radiation. The effects of UV radiation on skin functions should be investigated using human in vitro models to understand the mechanisms of skin ageing. Additionally, marine algae provide a valuable source for identifying and extracting biologically active substances. OBJECTIVES: In this study, sargachromanol E was isolated from a marine brown alga, Sargassum horneri, and its inhibitory effect on skin ageing was investigated using UVA-irradiated dermal fibroblasts. METHODS: RESULTS: CONCLUSIONS: This study suggests that UVA irradiation modulates MMP expression via the transcriptional activation of AP-1 signalling, whereas treatment with sargachromanol E protected cell damage caused by UVA irradiation.
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Authors | J-A Kim, B-N Ahn, C-S Kong, S-K Kim |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 168
Issue 5
Pg. 968-76
(May 2013)
ISSN: 1365-2133 [Electronic] England |
PMID | 23278330
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 The Authors. BJD © 2013 British Association of Dermatologists. |
Chemical References |
- Benzopyrans
- Radiation-Protective Agents
- Reactive Oxygen Species
- Tissue Inhibitor of Metalloproteinase-1
- Tissue Inhibitor of Metalloproteinases
- Tissue Inhibitor of Metalloproteinase-2
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 1
- sargachromanol E
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Topics |
- Benzopyrans
(metabolism, pharmacology)
- Blotting, Western
- Cells, Cultured
(drug effects)
- Fibroblasts
(drug effects, metabolism, radiation effects)
- Humans
- Lipid Peroxidation
(drug effects)
- Matrix Metalloproteinase 1
(genetics)
- Matrix Metalloproteinase 2
(genetics)
- Radiation-Protective Agents
(pharmacology)
- Reactive Oxygen Species
(metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Sargassum
(chemistry)
- Skin
(drug effects, metabolism, radiation effects)
- Skin Aging
(drug effects, radiation effects)
- Tissue Inhibitor of Metalloproteinase-1
(metabolism)
- Tissue Inhibitor of Metalloproteinase-2
(metabolism)
- Tissue Inhibitor of Metalloproteinases
(metabolism)
- Ultraviolet Rays
(adverse effects)
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