[Hepatic arterial infusion with subsequent hepatectomy for a sigmoid colon cancer patient with hepatic metastases-a case report].

Abstract

It is common to use systemic chemotherapy, instead of hepatic arterial infusion (HAI) of 5-fluorouracil (5-FU) or other cytotoxic agents, for unresectable hepatic metastases in colorectal cancer patients. Nevertheless, systemic administration of anticancer agents such as FOLFOX or FOLFIRI is sometimes difficult to continue for infirm patients. A 71-year-old female who had undergone sigmoidectomy for sigmoid colon cancer received HAI for 12 months because of big bilobar hepatic metastases and poor performance status. Thereafter, a two-stage hepatectomy(first, left lobe: second, S7+8 and S5) was performed successfully. She has been alive for 2.5 years after the first operation but with two small lung metastases in the left lobe. Because of bad performance status and her weak social and familial conditions, treatment with standard systemic chemotherapy could not be continued. In such cases, HAI should be performed if the metastases are limited to the liver.

• Authors: Masayuki Ando, Toshiaki Kurokawa, Hideaki Ganno, Yoshihisa Watayo, Akira Fukuda, Takeshi Nagahama, Katsunori Ami, Jun Takasaki, Hidetoshi Amagasa, Ryota Seki, Keiichi Fujiya, Kuniyoshi Arai, Shikofumi Tei, Yoichi Okada
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 39 Issue 12 Pg. 2237-9 (Nov 2012) ISSN: 0385-0684 [Print] Japan
• PMID: 23268035 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents

Topics

• Aged
• Antineoplastic Agents (administration & dosage, therapeutic use)
• Combined Modality Therapy
• Female
• Hepatectomy
• Humans
• Infusions, Intra-Arterial
• Liver Neoplasms (drug therapy, secondary, surgery)
• Sigmoid Neoplasms (drug therapy, pathology, surgery)