HAVcR-1 expression in human colorectal cancer and its effects on colorectal cancer cells in vitro.

Abstract

BACKGROUND:

Hepatitis A virus cellular receptor 1 (HAVcR-1) may function as part of the regulatory apparatus for tight junction in human endothelial cells, and is overexpressed in renal cell and ovarian clear cell carcinomas.

MATERIALS AND METHODS:

HAVcR-1 expression in colorectal cancer and matched background tissues was determined using quantitative-PCR. HAVcR-1 was overexpressed in three colorectal cancer cell lines and the effect of this overexpression was assessed by changes in cell behaviour.

RESULTS:

HAVcR-1 expression was increased in colorectal cancer (p<0.001) and the disease-free time of patients with high levels of HAVcR-1 expression was significantly longer (p=0.045). HAVcR-1 overexpression reduced colorectal cancer cell adhesion and invasion (p<0.016).

CONCLUSION:

HAVcR-1 overexpression may be a diagnostic biomarker for colorectal cancer and a prognostic marker for a longer disease-free interval after surgery for colorectal cancer. HAVcR-1 overexpression can reduce cell adhesion and invasion and could thus be involved in the metastatic cascade.

• Authors: Youxin Wang, Tracey A Martin, Wen G Jiang
• Journal: Anticancer research (Anticancer Res) Vol. 33 Issue 1 Pg. 207-14 (Jan 2013) ISSN: 1791-7530 [Electronic] Greece
• PMID: 23267147 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• HAVCR1 protein, human
• Hepatitis A Virus Cellular Receptor 1
• Membrane Glycoproteins
• Receptors, Virus

Topics

• Biomarkers, Tumor (genetics, metabolism)
• Caco-2 Cells
• Cell Adhesion (genetics)
• Colorectal Neoplasms (metabolism, pathology, therapy)
• Gene Expression Regulation, Neoplastic
• Hepatitis A Virus Cellular Receptor 1
• Humans
• Kaplan-Meier Estimate
• Membrane Glycoproteins (genetics, metabolism)
• Neoplasm Invasiveness (genetics)
• Neoplasm Metastasis
• Neoplasm Staging
• Prognosis
• Receptors, Virus (genetics, metabolism)