GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration.

Abstract	The regulation of cell migration is a highly complex process that is often compromised when cancer cells become metastatic. The microtubule cytoskeleton is necessary for cell migration, but how microtubules and microtubule-associated proteins regulate multiple pathways promoting cell migration remains unclear. Microtubule plus-end binding proteins (+TIPs) are emerging as important players in many cellular functions, including cell migration. Here we identify a +TIP, GTSE1, that promotes cell migration. GTSE1 accumulates at growing microtubule plus ends through interaction with the EB1+TIP. The EB1-dependent +TIP activity of GTSE1 is required for cell migration, as well as for microtubule-dependent disassembly of focal adhesions. GTSE1 protein levels determine the migratory capacity of both nontransformed and breast cancer cell lines. In breast cancers, increased GTSE1 expression correlates with invasive potential, tumor stage, and time to distant metastasis, suggesting that misregulation of GTSE1 expression could be associated with increased invasive potential.
Authors	Massimilano Scolz, Per O Widlund, Silvano Piazza, Debora Rosa Bublik, Simone Reber, Leticia Y Peche, Yari Ciani, Nina Hubner, Mayumi Isokane, Martin Monte, Jan Ellenberg, Anthony A Hyman, Claudio Schneider, Alexander W Bird
Journal	PloS one (PLoS One) Vol. 7 Issue 12 Pg. e51259 ( 2012) ISSN: 1932-6203 [Electronic] United States
PMID	23236459 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	DNA Primers GTSE1 protein, human MAPRE1 protein, human Microtubule-Associated Proteins RNA, Small Interfering
Topics	Breast Neoplasms (genetics, metabolism) Cell Line Cell Movement (physiology) DNA Primers (genetics) Female Fluorescent Antibody Technique Gene Expression Profiling Gene Expression Regulation, Neoplastic (genetics) Humans Immunoprecipitation Kaplan-Meier Estimate Mass Spectrometry Microscopy, Fluorescence Microtubule-Associated Proteins (metabolism) Microtubules (metabolism, physiology) Neoplasm Invasiveness (genetics) RNA Interference RNA, Small Interfering (genetics) Real-Time Polymerase Chain Reaction

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