Angiogenin variants are not associated with Parkinson's disease in the ethnic Chinese population.

Abstract

Recently, the angiogenin gene has been reported to be significantly associated with Parkinson's disease and amyotrophic lateral sclerosis in populations of European and American ancestry. But there have been no studies investigating the association between angiogenin and Parkinson's disease in the ethnic Chinese population. We conducted a case-control study to evaluate the association between angiogenin and Parkinson's disease in a Chinese population from mainland China. We sequenced the exons of angiogenin in 532 Parkinson's disease patients and 480 controls. We did not detect an angiogenin coding region mutation in either the patients or the controls. Our data do not support the association of angiogenin variants with PD in Han Chinese of mainland China.

• Authors: Bin Liu, Yu Zhang, Ying Wang, Qin Xiao, Qiong Yang, Gang Wang, Jianfang Ma, Jing Zhao, Thomas J Quinn, Sheng-di Chen, Jun Liu
• Journal: Parkinsonism & related disorders (Parkinsonism Relat Disord) Vol. 19 Issue 4 Pg. 446-7 (Apr 2013) ISSN: 1873-5126 [Electronic] England
• PMID: 23231972 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• angiogenin
• Ribonuclease, Pancreatic

Topics

• Adult
• Aged
• Aged, 80 and over
• Asian People (genetics)
• Case-Control Studies
• China (epidemiology)
• DNA Mutational Analysis
• Ethnicity (genetics)
• Female
• Genetic Association Studies
• Genetic Predisposition to Disease (genetics)
• Genetic Variation
• Humans
• Male
• Middle Aged
• Parkinson Disease (genetics)
• Reverse Transcriptase Polymerase Chain Reaction
• Ribonuclease, Pancreatic (genetics)
• Young Adult