HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Rhapontigenin converted from rhapontin purified from Rheum undulatum enhances the inhibition of melanin synthesis.

Abstract
Rhapontigenin was produced from rhapontin isolated from a methanol extract of Rheum undulatum roots by enzymatic transformation. Rhapontin and rhapontigenin exhibited dose-dependent inhibition of tyrosinase activity and melanin synthesis in B16F10 melanoma cells, but the inhibitory activity of rhapontigenin was greater than that of rhapontin. Thus the bioconversion of rhapontin enhanced its ability to inhibit cellular tyrosinase activity and melanin synthesis.
AuthorsHyun-Sun Lee, Jeong-Keun Kim, Keun-Tae Park, Young-Hee Lim
JournalBioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 76 Issue 12 Pg. 2307-9 ( 2012) ISSN: 1347-6947 [Electronic] England
PMID23221688 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Melanins
  • Stilbenes
  • rhapontigenin
  • rhapontin
Topics
  • Animals
  • Biotransformation
  • Cell Line, Tumor
  • Melanins (biosynthesis)
  • Mice
  • Rheum (chemistry)
  • Stilbenes (isolation & purification, metabolism, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: