Abstract | BACKGROUND: METHODS: Eighteen Sprague-Dawley rats were intubated, and acute lung injury was induced by aspiration of 0.1N HCl (1 mL/kg) through the tracheal tube. Inflow and outflow tubes were placed in the thoracic cavity and connected to a perfusion circuit containing a roller pump, warmer, and oxygenator. Rats in group I were not treated after aspiration of HCl, those in group II were perfused with oxygenated saline, and those in group III were perfused with oxygenated perfluorocarbon. Arterial blood gases were collected every 30 minutes for 180 minutes. At the last step of the experiments, pathological examination of the lungs and parietal pleura was performed. RESULTS: PaO(2) in group III was significantly higher than that in group I or II. PaCO(2) in group III was significantly lower than that in the other two groups. Histological examination showed relatively well-delineated zones of inflammation-free coagulative necrosis of lung parenchyma in all groups. CONCLUSIONS:
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Authors | Jeong Su Cho, Yeong Dae Kim, Nari Shin, Chang Hun Lee, Sukki Cho, Sanghoon Jheon |
Journal | Experimental lung research
(Exp Lung Res)
Vol. 39
Issue 1
Pg. 32-8
(Feb 2013)
ISSN: 1521-0499 [Electronic] England |
PMID | 23215869
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fluorocarbons
- Carbon Dioxide
- Oxygen
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Topics |
- Acute Lung Injury
(chemically induced, drug therapy, pathology)
- Animals
- Animals, Outbred Strains
- Blood Gas Analysis
(methods)
- Carbon Dioxide
(blood)
- Disease Models, Animal
- Fluorocarbons
(administration & dosage)
- Hemodynamics
(drug effects, physiology)
- Hypoventilation
(chemically induced, drug therapy, pathology)
- Lung
(drug effects, pathology)
- Male
- Necrosis
(chemically induced, pathology)
- Oxygen
(blood)
- Perfusion
(methods)
- Pulmonary Gas Exchange
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Thoracic Cavity
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