Abstract | OBJECTIVES:
Bloodstream infections are of great concerns and a major cause of mortality in solid-organ transplant recipients. This study investigated the possible predictors influencing survival among solid-organ transplant recipients with bloodstream infections. MATERIALS AND METHODS: We performed a retrospective analysis of bloodstream infections in patients who underwent solid-organ transplant between January 2002 and November 2011. During the study, 133 episodes of bloodstream infections occurred in 98 solid-organ transplant recipients. The predictors were identified by univariate and multivariate logistic regression analyses. RESULTS: The mean age for the 98 enrolled patients was 42.3 years (42.3 ± 12.8 y). The majority of infections were nosocomial (79.6%), and the bloodstream infection-related mortality rate was 39.8% (39 of 98 patients). The univariate analysis identified the following variables as predictors of bloodstream infection-related mortality: intra-abdominal/biliary focus (P = .011), polymicrobial infection (P < .001), liver transplant (P = .002), platelet count <50 000 × 109/L (P < .001), lymphocyte count <300 × 109/L (P = .027), and septic shock (P < .001). The multivariate logistic regression analysis identified platelet count < 50 000 × 109/L and septic shock as independent predictors of mortality. CONCLUSIONS:
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Authors | Qiquan Wan, Qifa Ye, Jiandang Zhou |
Journal | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
(Exp Clin Transplant)
Vol. 11
Issue 3
Pg. 211-4
(Jun 2013)
ISSN: 2146-8427 [Electronic] Turkey |
PMID | 23190439
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Chi-Square Distribution
- Child
- Communicable Diseases
(blood, etiology, mortality)
- Cross Infection
(blood, etiology, mortality)
- Female
- Humans
- Logistic Models
- Lymphocyte Count
- Male
- Middle Aged
- Multivariate Analysis
- Odds Ratio
- Organ Transplantation
(adverse effects, mortality)
- Platelet Count
- Predictive Value of Tests
- Prognosis
- Retrospective Studies
- Risk Assessment
- Risk Factors
- Shock, Septic
(blood, etiology, mortality)
- Time Factors
- Young Adult
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