A bioinorganic view of Alzheimer's disease: when misplaced metal ions (re)direct the electrons to the wrong target.

Abstract

Metal ions Cu, Zn and Fe, seem to play a pivotal role in Alzheimer's disease and other neurodegenerative diseases. In order to understand this in a broader sense, one has to considerer the peculiarities of metal metabolism in the brain compared to most other tissues, as well as the importance of the redox active metal ions, Fe and Cu, in oxygen metabolism and the connected oxidative stress.

• Authors: Peter Faller, Christelle Hureau
• Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (Chemistry) Vol. 18 Issue 50 Pg. 15910-20 (Dec 07 2012) ISSN: 1521-3765 [Electronic] Germany
• PMID: 23180511 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Ions
• Metals

Topics

• Alzheimer Disease (metabolism, pathology)
• Brain (metabolism, pathology)
• Electrons
• Humans
• Ions (chemistry, metabolism)
• Metals (chemistry, metabolism)
• Neurodegenerative Diseases (metabolism)
• Oxidation-Reduction
• Oxidative Stress