Abstract |
This randomized, double-blind, placebo-controlled crossover study compared inhibition by one 5 mg dose of levocetirizine with two 60 mg doses of fexofenadine separated by 12 h of histamine-induced wheal and flare responses in 9 Caucasian and 9 Japanese healthy male volunteers. Levocetirizine was more inhibitory than fexofenadine on wheal, flare and pruritus (p < 0.005). Variability, evaluated from the standard deviation of inhibition, ranged from 14% to 23.2% for levocetirizine and 65.4% to 112.4% for fexofenadine. Levocetirizine had a faster onset of action (30-90 min versus 2 h), shorter time to maximum effect (3-4 versus 3-6 h) and longer duration of action (at least 24 h versus ~12 h) than fexofenadine. The plasma levels of levocetirizine rose more quickly, reached higher levels, were more consistent and decreased slower than those of fexofenadine. There were no clinically significant ethnic differences in responsiveness to the drugs.
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Authors | Nicole Schoepke, Martin K Church, Marcus Maurer |
Journal | Acta dermato-venereologica
(Acta Derm Venereol)
Vol. 93
Issue 3
Pg. 286-93
(May 2013)
ISSN: 1651-2057 [Electronic] Sweden |
PMID | 23147964
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Histamine H1 Antagonists, Non-Sedating
- levocetirizine
- Terfenadine
- Histamine
- fexofenadine
- Cetirizine
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Topics |
- Adult
- Asian People
- Cetirizine
(blood, therapeutic use)
- Cross-Over Studies
- Dose-Response Relationship, Drug
- Double-Blind Method
- Germany
(epidemiology)
- Histamine
(administration & dosage)
- Histamine H1 Antagonists, Non-Sedating
(blood, therapeutic use)
- Humans
- Japan
(ethnology)
- Male
- Pruritus
(chemically induced, ethnology, pathology, prevention & control)
- Skin
(drug effects, pathology)
- Terfenadine
(analogs & derivatives, blood, therapeutic use)
- Time Factors
- Treatment Outcome
- Urticaria
(chemically induced, ethnology, pathology, prevention & control)
- White People
- Young Adult
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