Abstract | OBJECTIVE: METHODS: A retrospective review was conducted of patients undergoing radical hysterectomy from 2000 to 2010 with Stage IA2-IIA cervical cancer. CSM were defined as ≤5mm; association with other clinicopathologic factors as well as recurrence and survival was evaluated. RESULTS: Of the 119 patients, 75 (63%) with CSM had a recurrence rate of 24% compared to 9% without CSM. Though not independently associated with recurrence, CSM were significantly associated with positive lymph nodes (44% vs. 18%), positive parametria (33.3% vs. 2.3%), larger tumors (3.5 vs. 2.5cm), greater depth of stromal invasion (DOI) (84% vs. 33%), and lymphovascular space invasion (LVSI) (61.3% vs. 34.1%). We failed to find an association between adjuvant therapy and recurrence in those with CSM. Exploratory analysis revealed that a surgical margin of ≤2mm was significantly associated with an increased risk of overall recurrence (36% vs. 9%, p=0.009) as well as loco-regional recurrence (22% vs. 4%, p=0.0034). CONCLUSIONS:
Surgical margins of ≤5mm on radical hysterectomy specimens are often associated with other high or intermediate risk factors for recurrence. While not a proven independent risk factor, the distance to surgical margin may warrant further investigation as an intermediate risk factor along with tumor size, DOI and LVSI.
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Authors | Georgia A McCann, Susanne K Taege, Christina E Boutsicaris, Gary S Phillips, Eric L Eisenhauer, Jeffrey M Fowler, David M O'Malley, Larry J Copeland, David E Cohn, Ritu Salani |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 128
Issue 1
Pg. 44-48
(Jan 2013)
ISSN: 1095-6859 [Electronic] United States |
PMID | 23138134
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Topics |
- Adult
- Female
- Humans
- Hysterectomy
- Middle Aged
- Neoplasm Invasiveness
- Neoplasm Recurrence, Local
(etiology, pathology)
- Neoplasm Staging
- Retrospective Studies
- Uterine Cervical Neoplasms
(mortality, pathology, surgery)
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